.
This commit is contained in:
Ross
@@ -32,15 +32,13 @@ breadcrumbs:
|
||||
category: "Brain"
|
||||
documentVersionId: "259b8c88-93cc-45d6-93d8-75d279e9ead2"
|
||||
imageCount: 12
|
||||
isBookmarked: false
|
||||
isComparable: true
|
||||
isInCompareCart: false
|
||||
lastUpdated: "08/05/20"
|
||||
pageDescription: "CLIPPERS"
|
||||
pageKeywords: "Brain, Diagnosis, Pathology-Based Diagnoses, Infectious, Inflammatory, and Demyelinating Disease, Inflammatory and Demyelinating Disease, CLIPPERS"
|
||||
pageTitle: "CLIPPERS | STATdx"
|
||||
enhancedTitle: "CLIPPERS"
|
||||
type: "DX"
|
||||
references: true
|
||||
breadcrumbs:
|
||||
- "Brain"
|
||||
- "Diagnosis"
|
||||
@@ -256,42 +254,84 @@ breadcrumbs:
|
||||
|
||||
0e17b374-1564-4020-a6e2-552480332e98
|
||||
|
||||
## References
|
||||
|
||||
# Selected References
|
||||
|
||||
1. [Li Z et al: CLIPPERS, a syndrome of lymphohistiocytic disorders. Mult Scler Relat Disord. 42:102063, 2020](http://www.ncbi.nlm.nih.gov/pubmed/?term=32234602%5Bpmid%5D)
|
||||
1. [Turnquist C et al: CLIPPERS: a case report with radiology, three serial biopsies and a literature review. Clin Neuropathol. 39(1):19-24, 2020](http://www.ncbi.nlm.nih.gov/pubmed/?term=31661071%5Bpmid%5D)
|
||||
1. [Taieb G et al: CLIPPERS and its mimics: evaluation of new criteria for the diagnosis of CLIPPERS. J Neurol Neurosurg Psychiatry. 90(9):1027-38, 2019](http://www.ncbi.nlm.nih.gov/pubmed/?term=31072955%5Bpmid%5D)
|
||||
1. [Berzero G et al: CLIPPERS mimickers: relapsing brainstem encephalitis associated with anti-MOG antibodies. Eur J Neurol. 25(2):e16-7, 2018](http://www.ncbi.nlm.nih.gov/pubmed/?term=29356261%5Bpmid%5D)
|
||||
1. [Tian D et al: Case 259: Primary central nervous system lymphomatoid granulomatosis mimicking chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). Radiology. 289(2):572-7, 2018](http://www.ncbi.nlm.nih.gov/pubmed/?term=30332362%5Bpmid%5D)
|
||||
1. [Tobin WO et al: Diagnostic criteria for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). Brain. 140(9):2415-25, 2017](http://www.ncbi.nlm.nih.gov/pubmed/?term=29050399%5Bpmid%5D)
|
||||
1. [Taieb G et al: Punctate and curvilinear gadolinium enhancing lesions in the brain: a practical approach. Neuroradiology. 58(3):221-35, 2016](http://www.ncbi.nlm.nih.gov/pubmed/?term=26700824%5Bpmid%5D)
|
||||
1. [Gul M et al: Atypical presentation of CLIPPERS syndrome: a new entity in the differential diagnosis of central nervous system rheumatologic diseases. J Clin Rheumatol. 21(3):144-8, 2015](http://www.ncbi.nlm.nih.gov/pubmed/?term=25807094%5Bpmid%5D)
|
||||
1. [Dudesek A et al: CLIPPERS: chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. Review of an increasingly recognized entity within the spectrum of inflammatory central nervous system disorders. Clin Exp Immunol. 175(3):385-96, 2014](http://www.ncbi.nlm.nih.gov/pubmed/?term=24028073%5Bpmid%5D)
|
||||
1. [Pittock SJ et al: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). Brain. 133(9):2626-34, 2010](http://www.ncbi.nlm.nih.gov/pubmed/?term=20639547%5Bpmid%5D)
|
||||
|
||||
|
||||
## Images
|
||||
|
||||
|
||||
### Selected Images
|
||||
|
||||
|
||||
*Sagittal FLAIR MR in a 56-year-old woman with weight loss and a 3-week history of diplopia and disequilibrium shows confluent and punctate hyperintensities in the pons <img src='/img/arrows/WO.png'/> and medulla <img src='/img/arrows/WS.png'/>.*
|
||||
|
||||
|
||||
*Sagittal FLAIR MR in a 56-year-old woman with weight loss and a 3-week history of diplopia and disequilibrium shows confluent and punctate hyperintensities in the pons <img src='/img/arrows/WO.png'/> and medulla <img src='/img/arrows/WS.png'/>.*
|
||||
|
||||
|
||||
|
||||
*Sagittal FLAIR MR in a 56-year-old woman with weight loss and a 3-week history of diplopia and disequilibrium shows confluent and punctate hyperintensities in the pons <img src='/img/arrows/WO.png'/> and medulla <img src='/img/arrows/WS.png'/>.*
|
||||
|
||||
|
||||
*Axial T1 C+ MR in the same patient shows multiple punctate and curvilinear enhancing foci "peppering" the pons <img src='/img/arrows/WS.png'/>. Additional lesions are present in both cerebellar peduncles, vermis, and the left cerebellar hemisphere.*
|
||||
|
||||
|
||||
*Axial T1 C+ MR in the same patient shows multiple punctate and curvilinear enhancing foci "peppering" the pons <img src='/img/arrows/WS.png'/>. Additional lesions are present in both cerebellar peduncles, vermis, and the left cerebellar hemisphere.*
|
||||
|
||||
|
||||
*More cephalad T1 C+ MR scan in the same patient shows the punctate <img src='/img/arrows/WS.png'/> and curvilinear <img src='/img/arrows/WC.png'/> lesions involving the upper pons.*
|
||||
|
||||
|
||||
*More cephalad T1 C+ MR scan in the same patient shows the punctate <img src='/img/arrows/WS.png'/> and curvilinear <img src='/img/arrows/WC.png'/> lesions involving the upper pons.*
|
||||
|
||||
|
||||
*Coronal T1 C+ FS MR in the same patient shows the lesions "peppering" the pons. Note cephalad extension into the cerebral peduncles <img src='/img/arrows/WO.png'/> and inferior extension into the medulla <img src='/img/arrows/WC.png'/> and upper cervical cord <img src='/img/arrows/WS.png'/>. DSA (not shown) was negative. The lesions resolved with corticosteroids, so this is a presumed case of CLIPPERS.*
|
||||
|
||||
|
||||
*Coronal T1 C+ FS MR in the same patient shows the lesions "peppering" the pons. Note cephalad extension into the cerebral peduncles <img src='/img/arrows/WO.png'/> and inferior extension into the medulla <img src='/img/arrows/WC.png'/> and upper cervical cord <img src='/img/arrows/WS.png'/>. DSA (not shown) was negative. The lesions resolved with corticosteroids, so this is a presumed case of CLIPPERS.*
|
||||
|
||||
|
||||
### Additional Images
|
||||
|
||||
|
||||
*Sagittal FLAIR in a 52-year-old man with diplopia, dysarthria, and facial numbness shows confluent hyperintensity in the pons <img src='/img/arrows/WS.png'/>.*
|
||||
|
||||
|
||||
*Sagittal FLAIR in a 52-year-old man with diplopia, dysarthria, and facial numbness shows confluent hyperintensity in the pons <img src='/img/arrows/WS.png'/>.*
|
||||
|
||||
|
||||
*Axial T1 C+ MR shows scattered, faint, punctate enhancing foci <img src='/img/arrows/WS.png'/> as well as larger confluent, nodular <img src='/img/arrows/WO.png'/>, and partial ring-enhancing <img src='/img/arrows/WC.png'/> lesions in the pons.*
|
||||
|
||||
|
||||
*Axial T1 C+ MR shows scattered, faint, punctate enhancing foci <img src='/img/arrows/WS.png'/> as well as larger confluent, nodular <img src='/img/arrows/WO.png'/>, and partial ring-enhancing <img src='/img/arrows/WC.png'/> lesions in the pons.*
|
||||
|
||||
|
||||
*Coronal T1 C+ MR in the same patient shows large, confluent, patchy enhancing lesions <img src='/img/arrows/WS.png'/> in the pons. Differential diagnosis included lymphoma, lymphomatoid granulomatosis, vasculitis, and CLIPPERS. The patient improved on steroids.*
|
||||
|
||||
|
||||
*Coronal T1 C+ MR in the same patient shows large, confluent, patchy enhancing lesions <img src='/img/arrows/WS.png'/> in the pons. Differential diagnosis included lymphoma, lymphomatoid granulomatosis, vasculitis, and CLIPPERS. The patient improved on steroids.*
|
||||
|
||||
|
||||
*Sagittal FLAIR in the same patient obtained a year later when symptoms relapsed off steroids shows multiple punctate hyperintensities "peppering" the pons <img src='/img/arrows/WS.png'/> and medulla <img src='/img/arrows/WC.png'/>. Note extension into upper spinal cord <img src='/img/arrows/WO.png'/>.*
|
||||
|
||||
|
||||
*Sagittal FLAIR in the same patient obtained a year later when symptoms relapsed off steroids shows multiple punctate hyperintensities "peppering" the pons <img src='/img/arrows/WS.png'/> and medulla <img src='/img/arrows/WC.png'/>. Note extension into upper spinal cord <img src='/img/arrows/WO.png'/>.*
|
||||
|
||||
|
||||
*Axial T1 C + FS MR in the same patient shows small, punctate foci of enhancement <img src='/img/arrows/WS.png'/> "peppering" the pons, cerebellar peduncles.*
|
||||
|
||||
|
||||
*Axial T1 C + FS MR in the same patient shows small, punctate foci of enhancement <img src='/img/arrows/WS.png'/> "peppering" the pons, cerebellar peduncles.*
|
||||
|
||||
|
||||
Reference in New Issue
Block a user