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docs_md/articles/multiinfarct-dementia_3823c4d4-5e98-46da-a717-892fef54b382.md
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slug: "multiinfarct-dementia"
treeNodeId: null
category: "Nuclear Medicine"
cmeTopicId: "b2cd9aea-3e6d-4c30-9fd7-e49cc48a4549"
cmeTopicId: "29e9ca9b-f22e-44aa-94a4-19393851339d"
documentVersionId: "2906e1eb-a93a-4cdb-8e7f-261c406e626c"
imageCount: 24
lastUpdated: "07/21/25"
@@ -232,7 +232,7 @@ breadcrumbs:
- Lesions can include basal ganglia and other areas typically spared in other diseases
- MR correlation helpful
7855ad33-290d-4bb0-81a6-63126fea7e4f
18eb7ef1-b90d-42fa-ae9c-fe185e01420c
## References
@@ -252,90 +252,84 @@ breadcrumbs:
### Selected Images
![Axial graphic shows multifocal infarcts involving the cortical gray matter and subcortical white matter bilaterally.](images/app.statdx.com_image_thumbnail_9790b351-4019-4c6d-aa10-5f455976b073_size_168_quality_85_6c88d907_20251014T185335Z.jpg)
![Axial graphic shows multifocal infarcts involving the cortical gray matter and subcortical white matter bilaterally.](images/app.statdx.com_image_thumbnail_9790b351-4019-4c6d-aa10-5f455976b073_annotated_true_size_900_quality_90_e612492c0e4b5b90392f19e2a031291d7d77a3c4.jpg)
*Axial graphic shows multifocal infarcts involving the cortical gray matter and subcortical white matter bilaterally.*
![Axial graphic shows multifocal infarcts involving the cortical gray matter and subcortical white matter bilaterally.](images/app.statdx.com_image_thumbnail_9790b351-4019-4c6d-aa10-5f455976b073_size_174_quality_85_0a048a3c_20251014T193347Z.jpg)
![Axial graphic shows multifocal infarcts involving the cortical gray matter and subcortical white matter bilaterally.](images/app.statdx.com_image_thumbnail_9790b351-4019-4c6d-aa10-5f455976b073_size_174_quality_85_4cd6459c_20251018T155131Z.jpg)
*Axial graphic shows multifocal infarcts involving the cortical gray matter and subcortical white matter bilaterally.*
![Axial graphic shows multifocal infarcts involving the cortical gray matter and subcortical white matter bilaterally.](images/app.statdx.com_image_thumbnail_9790b351-4019-4c6d-aa10-5f455976b073_size_174_quality_85_34cad0d2_20251014T185333Z.jpg)
![Axial graphic shows multifocal infarcts involving the cortical gray matter and subcortical white matter bilaterally.](images/app.statdx.com_image_thumbnail_9790b351-4019-4c6d-aa10-5f455976b073_size_174_quality_85_a77e98a4d69e6053f6faa6bb10086de75ace83d3.jpg)
*Axial graphic shows multifocal infarcts involving the cortical gray matter and subcortical white matter bilaterally.*
![Axial graphic shows multifocal infarcts involving the cortical gray matter and subcortical white matter bilaterally.](images/app.statdx.com_image_thumbnail_9790b351-4019-4c6d-aa10-5f455976b073_size_174_quality_85_63b05924_20251014T190917Z.jpg)
*Axial graphic shows multifocal infarcts involving the cortical gray matter and subcortical white matter bilaterally.*
![Axial graphic shows multifocal infarcts involving the cortical gray matter and subcortical white matter bilaterally.](images/app.statdx.com_image_thumbnail_9790b351-4019-4c6d-aa10-5f455976b073_size_174_quality_85_85ee028f_20251014T204456Z.jpg)
*Axial graphic shows multifocal infarcts involving the cortical gray matter and subcortical white matter bilaterally.*
![Coronal FLAIR MR of a 72-year-old woman demonstrates FLAIR signal abnormality in the periventricular and subcortical white matter (leukoaraiosis). This finding is consistent with a small vessel ischemic etiology.](images/app.statdx.com_image_thumbnail_e246e10c-9118-4293-96d2-18d1dc8192be_size_168_quality_85_00df6db0_20251014T185335Z.jpg)
![Coronal FLAIR MR of a 72-year-old woman demonstrates FLAIR signal abnormality in the periventricular and subcortical white matter (leukoaraiosis). This finding is consistent with a small vessel ischemic etiology.](images/app.statdx.com_image_thumbnail_e246e10c-9118-4293-96d2-18d1dc8192be_annotated_true_size_900_quality_90_38b46fb1ab1a335e57eed6ee88f2205029e9d5dd.jpg)
*Coronal FLAIR MR of a 72-year-old woman demonstrates FLAIR signal abnormality in the periventricular and subcortical white matter (leukoaraiosis). This finding is consistent with a small vessel ischemic etiology.*
![Surface mapping of an FDG PET scan performed in a 96-year-old man demonstrates multiple areas of significant cortical abnormality in glucose metabolism, including the left frontal lobe <img src='img/arrows/CS.png'/>, the right occipital lobe <img src='img/arrows/CC.png'/> and the cingulate gyrus <img src='img/arrows/CO.png'/>, consistent with multiinfarct dementia.](images/app.statdx.com_image_thumbnail_5f66168d-7754-460f-9e67-f9e5338828e7_size_168_quality_85_a11fae3d_20251014T185335Z.jpg)
![Surface mapping of an FDG PET scan performed in a 96-year-old man demonstrates multiple areas of significant cortical abnormality in glucose metabolism, including the left frontal lobe <img src='img/arrows/CS.png'/>, the right occipital lobe <img src='img/arrows/CC.png'/> and the cingulate gyrus <img src='img/arrows/CO.png'/>, consistent with multiinfarct dementia.](images/app.statdx.com_image_thumbnail_5f66168d-7754-460f-9e67-f9e5338828e7_annotated_true_size_900_quality_90_e93c4d26b79a5d5f933d169bd4b8835bc499bff1.jpg)
*Surface mapping of an FDG PET scan performed in a 96-year-old man demonstrates multiple areas of significant cortical abnormality in glucose metabolism, including the left frontal lobe <img src='img/arrows/CS.png'/>, the right occipital lobe <img src='img/arrows/CC.png'/> and the cingulate gyrus <img src='img/arrows/CO.png'/>, consistent with multiinfarct dementia.*
![Axial F-18 FDG PET in a patient presenting with dementia shows more unilateral areas of hypometabolism <img src='img/arrows/WS.png'/> and globally decreased F-18 FDG uptake, also consistent with vascular dementia (VaD).](images/app.statdx.com_image_thumbnail_d2ae652b-f028-4e9e-9cac-3b360345030e_size_168_quality_85_cbe960cd_20251014T185335Z.jpg)
![Axial F-18 FDG PET in a patient presenting with dementia shows more unilateral areas of hypometabolism <img src='img/arrows/WS.png'/> and globally decreased F-18 FDG uptake, also consistent with vascular dementia (VaD).](images/app.statdx.com_image_thumbnail_d2ae652b-f028-4e9e-9cac-3b360345030e_annotated_true_size_900_quality_90_492fa70c1930f37903e3700341b443818a337817.jpg)
*Axial F-18 FDG PET in a patient presenting with dementia shows more unilateral areas of hypometabolism <img src='img/arrows/WS.png'/> and globally decreased F-18 FDG uptake, also consistent with vascular dementia (VaD).*
### Additional Images
![Alzheimer dementia is shown. Note the parietal and posterior temporal reductions <img src='img/arrows/WS.png'/> and sparing of occipital and frontal lobes.](images/app.statdx.com_image_thumbnail_dc0a1eed-2c05-4a79-8b17-8b509ec07cfd_size_168_quality_85_07b57a2c_20251014T185335Z.jpg)
![Alzheimer dementia is shown. Note the parietal and posterior temporal reductions <img src='img/arrows/WS.png'/> and sparing of occipital and frontal lobes.](images/app.statdx.com_image_thumbnail_dc0a1eed-2c05-4a79-8b17-8b509ec07cfd_annotated_true_size_900_quality_90_7d6c06e379c64647140a1a8f315addd9005be8ea.jpg)
*Alzheimer dementia is shown. Note the parietal and posterior temporal reductions <img src='img/arrows/WS.png'/> and sparing of occipital and frontal lobes.*
![Frontotemporal dementia (FTD) is shown. Note the frontal and anterior temporal reductions <img src='img/arrows/WS.png'/> and sparing of parietal, posterior temporal, and occipital regions.](images/app.statdx.com_image_thumbnail_0038934c-33bc-4eb2-b4a8-3b0f64fe0315_size_168_quality_85_f569ead3_20251014T185335Z.jpg)
![Frontotemporal dementia (FTD) is shown. Note the frontal and anterior temporal reductions <img src='img/arrows/WS.png'/> and sparing of parietal, posterior temporal, and occipital regions.](images/app.statdx.com_image_thumbnail_0038934c-33bc-4eb2-b4a8-3b0f64fe0315_annotated_true_size_900_quality_90_f625ae4d56bfd3c8d5c81dd9425e29795f356aae.jpg)
*Frontotemporal dementia (FTD) is shown. Note the frontal and anterior temporal reductions <img src='img/arrows/WS.png'/> and sparing of parietal, posterior temporal, and occipital regions.*
![Axial FDG PET in a patient with Lewy body disease shows parietal and posterior temporal reduction similar to Alzheimer disease (AD) <img src='img/arrows/WS.png'/>, but occipital cortex <img src='img/arrows/WO.png'/> is also involved.](images/app.statdx.com_image_thumbnail_cae51cd3-ac69-4862-9d82-17078b4400c9_size_168_quality_85_0d46f630_20251014T185335Z.jpg)
![Axial FDG PET in a patient with Lewy body disease shows parietal and posterior temporal reduction similar to Alzheimer disease (AD) <img src='img/arrows/WS.png'/>, but occipital cortex <img src='img/arrows/WO.png'/> is also involved.](images/app.statdx.com_image_thumbnail_cae51cd3-ac69-4862-9d82-17078b4400c9_annotated_true_size_900_quality_90_631ae1b35164ac73c19d8d7005109487a4e6639f.jpg)
*Axial FDG PET in a patient with Lewy body disease shows parietal and posterior temporal reduction similar to Alzheimer disease (AD) <img src='img/arrows/WS.png'/>, but occipital cortex <img src='img/arrows/WO.png'/> is also involved.*
![Surface-rendered Tc-99m ECD SPECT in the same patient demonstrates severe reductions of parietal, temporal <img src='img/arrows/WS.png'/>, and occipital cortex <img src='img/arrows/WO.png'/>.](images/app.statdx.com_image_thumbnail_a10afb36-9b79-4677-b169-810b6303285b_size_168_quality_85_7735c389_20251014T185335Z.jpg)
![Surface-rendered Tc-99m ECD SPECT in the same patient demonstrates severe reductions of parietal, temporal <img src='img/arrows/WS.png'/>, and occipital cortex <img src='img/arrows/WO.png'/>.](images/app.statdx.com_image_thumbnail_a10afb36-9b79-4677-b169-810b6303285b_annotated_true_size_900_quality_90_6750937d4f73250ac4388139f46f8c71b5844319.jpg)
*Surface-rendered Tc-99m ECD SPECT in the same patient demonstrates severe reductions of parietal, temporal <img src='img/arrows/WS.png'/>, and occipital cortex <img src='img/arrows/WO.png'/>.*
![Axial FDG PET in a case of autopsy-proven Creutzfeldt-Jakob disease (CJD) shows multiple cortical defects <img src='img/arrows/WS.png'/>.](images/app.statdx.com_image_thumbnail_8d3cc9ee-c700-4302-b0ff-c256f3e6f9cc_size_168_quality_85_82b6b0bf_20251014T185335Z.jpg)
![Axial FDG PET in a case of autopsy-proven Creutzfeldt-Jakob disease (CJD) shows multiple cortical defects <img src='img/arrows/WS.png'/>.](8d3cc9ee-c700-4302-b0ff-c256f3e6f9cc)
*Axial FDG PET in a case of autopsy-proven Creutzfeldt-Jakob disease (CJD) shows multiple cortical defects <img src='img/arrows/WS.png'/>.*
![Surface-rendered Tc-99m ECD SPECT shows a pattern similar to AD <img src='img/arrows/WS.png'/>; however, clinical course was that of a rapid progressive dementia ending in death within 12 months of onset.](images/app.statdx.com_image_thumbnail_9ca30abf-17a2-4fc4-8ce2-d132b969f4c3_size_168_quality_85_cd6dbb00_20251014T185335Z.jpg)
![Surface-rendered Tc-99m ECD SPECT shows a pattern similar to AD <img src='img/arrows/WS.png'/>; however, clinical course was that of a rapid progressive dementia ending in death within 12 months of onset.](9ca30abf-17a2-4fc4-8ce2-d132b969f4c3)
*Surface-rendered Tc-99m ECD SPECT shows a pattern similar to AD <img src='img/arrows/WS.png'/>; however, clinical course was that of a rapid progressive dementia ending in death within 12 months of onset.*
![Axial Tc-99m ECD SPECT in a patient with clinical progressive supranuclear palsy (PSP) presentation shows severe frontal lobe decrease <img src='img/arrows/WO.png'/> and mild reduction in caudate heads <img src='img/arrows/WS.png'/>.](images/app.statdx.com_image_thumbnail_5dbf31bd-7f7f-4ce3-88da-c58bf3af58cf_size_168_quality_85_3d5a2562_20251014T185335Z.jpg)
![Axial Tc-99m ECD SPECT in a patient with clinical progressive supranuclear palsy (PSP) presentation shows severe frontal lobe decrease <img src='img/arrows/WO.png'/> and mild reduction in caudate heads <img src='img/arrows/WS.png'/>.](5dbf31bd-7f7f-4ce3-88da-c58bf3af58cf)
*Axial Tc-99m ECD SPECT in a patient with clinical progressive supranuclear palsy (PSP) presentation shows severe frontal lobe decrease <img src='img/arrows/WO.png'/> and mild reduction in caudate heads <img src='img/arrows/WS.png'/>.*
![Surface-rendered Tc-99m ECD SPECT demonstrates severe frontal decrease relative to parietal and occipital cortex <img src='img/arrows/WS.png'/>.](images/app.statdx.com_image_thumbnail_f145bf5c-b0f4-4973-983c-a9b658e92b51_size_168_quality_85_56feecd7_20251014T185335Z.jpg)
![Surface-rendered Tc-99m ECD SPECT demonstrates severe frontal decrease relative to parietal and occipital cortex <img src='img/arrows/WS.png'/>.](f145bf5c-b0f4-4973-983c-a9b658e92b51)
*Surface-rendered Tc-99m ECD SPECT demonstrates severe frontal decrease relative to parietal and occipital cortex <img src='img/arrows/WS.png'/>.*
![Axial Tc-99m ECD SPECT (baseline) in a patient with early FTD shows frontal atrophy and mild reduction in perfusion <img src='img/arrows/WS.png'/>.](images/app.statdx.com_image_thumbnail_17db9962-38b6-4fbc-9b7b-195575bfe8ab_size_168_quality_85_a6fe0add_20251014T185335Z.jpg)
![Axial Tc-99m ECD SPECT (baseline) in a patient with early FTD shows frontal atrophy and mild reduction in perfusion <img src='img/arrows/WS.png'/>.](17db9962-38b6-4fbc-9b7b-195575bfe8ab)
*Axial Tc-99m ECD SPECT (baseline) in a patient with early FTD shows frontal atrophy and mild reduction in perfusion <img src='img/arrows/WS.png'/>.*
![Axial Tc-99m ECD SPECT in the same patient (18 months post baseline) demonstrates significant decrease of frontal lobe activity from baseline study <img src='img/arrows/WS.png'/>, consistent with worsening dementia.](images/app.statdx.com_image_thumbnail_37c87d61-a119-4f80-81ce-8e922b6b0135_size_168_quality_85_f8a0896c_20251014T185335Z.jpg)
![Axial Tc-99m ECD SPECT in the same patient (18 months post baseline) demonstrates significant decrease of frontal lobe activity from baseline study <img src='img/arrows/WS.png'/>, consistent with worsening dementia.](37c87d61-a119-4f80-81ce-8e922b6b0135)
*Axial Tc-99m ECD SPECT in the same patient (18 months post baseline) demonstrates significant decrease of frontal lobe activity from baseline study <img src='img/arrows/WS.png'/>, consistent with worsening dementia.*
![Surface-rendered Tc-99m ECD SPECT of the same patient (baseline) demonstrates mild frontal lobe findings <img src='img/arrows/WS.png'/>.](images/app.statdx.com_image_thumbnail_01786172-6162-42ed-8a05-a359c16f3759_size_168_quality_85_e5c22c4a_20251014T185335Z.jpg)
![Surface-rendered Tc-99m ECD SPECT of the same patient (baseline) demonstrates mild frontal lobe findings <img src='img/arrows/WS.png'/>.](01786172-6162-42ed-8a05-a359c16f3759)
*Surface-rendered Tc-99m ECD SPECT of the same patient (baseline) demonstrates mild frontal lobe findings <img src='img/arrows/WS.png'/>.*
![Surface-rendered Tc-99m ECD SPECT 18 months post baseline demonstrates worsening <img src='img/arrows/WS.png'/>.](images/app.statdx.com_image_thumbnail_7956ee69-e5c6-425d-acc1-3d7a5f0add80_size_168_quality_85_080249b3_20251014T185335Z.jpg)
![Surface-rendered Tc-99m ECD SPECT 18 months post baseline demonstrates worsening <img src='img/arrows/WS.png'/>.](7956ee69-e5c6-425d-acc1-3d7a5f0add80)
*Surface-rendered Tc-99m ECD SPECT 18 months post baseline demonstrates worsening <img src='img/arrows/WS.png'/>.*
![Axial FDG PET in a patient with Huntington disease and mild dementia shows severe reduction in basal ganglia <img src='img/arrows/WS.png'/>.](images/app.statdx.com_image_thumbnail_e4888ead-8358-4e9f-bd18-4ec6c29e084b_size_168_quality_85_f5cdab9e_20251014T185335Z.jpg)
![Axial FDG PET in a patient with Huntington disease and mild dementia shows severe reduction in basal ganglia <img src='img/arrows/WS.png'/>.](e4888ead-8358-4e9f-bd18-4ec6c29e084b)
*Axial FDG PET in a patient with Huntington disease and mild dementia shows severe reduction in basal ganglia <img src='img/arrows/WS.png'/>.*
![Surface-rendered Tc-99m ECD SPECT in the same patient shows mild frontal <img src='img/arrows/WO.png'/> and parietal reductions <img src='img/arrows/WS.png'/>.](images/app.statdx.com_image_thumbnail_e12e1edb-5d84-4862-8739-3d32d0ad0b88_size_168_quality_85_5cef7127_20251014T185335Z.jpg)
![Surface-rendered Tc-99m ECD SPECT in the same patient shows mild frontal <img src='img/arrows/WO.png'/> and parietal reductions <img src='img/arrows/WS.png'/>.](e12e1edb-5d84-4862-8739-3d32d0ad0b88)
*Surface-rendered Tc-99m ECD SPECT in the same patient shows mild frontal <img src='img/arrows/WO.png'/> and parietal reductions <img src='img/arrows/WS.png'/>.*
![Surface-rendered Tc-99m ECD SPECT in a patient with normal pressure hydrocephalus (NPH) shows severe frontal and parietal defects <img src='img/arrows/WS.png'/> with preservation of vertex <img src='img/arrows/WO.png'/>.](images/app.statdx.com_image_thumbnail_07edad0d-74ce-4a31-9dff-da1fc76be8ba_size_168_quality_85_688dbc4f_20251014T185335Z.jpg)
![Surface-rendered Tc-99m ECD SPECT in a patient with normal pressure hydrocephalus (NPH) shows severe frontal and parietal defects <img src='img/arrows/WS.png'/> with preservation of vertex <img src='img/arrows/WO.png'/>.](07edad0d-74ce-4a31-9dff-da1fc76be8ba)
*Surface-rendered Tc-99m ECD SPECT in a patient with normal pressure hydrocephalus (NPH) shows severe frontal and parietal defects <img src='img/arrows/WS.png'/> with preservation of vertex <img src='img/arrows/WO.png'/>.*
![In-111 DTPA cisternogram (24 hours) in the same patient shows abnormal ventricular activity <img src='img/arrows/BS.png'/>.](images/app.statdx.com_image_thumbnail_b2483042-f995-4199-ab60-52d0e7c6144d_size_168_quality_85_f157c45a_20251014T185335Z.jpg)
![In-111 DTPA cisternogram (24 hours) in the same patient shows abnormal ventricular activity <img src='img/arrows/BS.png'/>.](b2483042-f995-4199-ab60-52d0e7c6144d)
*In-111 DTPA cisternogram (24 hours) in the same patient shows abnormal ventricular activity <img src='img/arrows/BS.png'/>.*
![Axial Tc-99m ECD SPECT in a patient with multiinfarct dementia shows multiple infarcts of the frontal and parietal cortex <img src='img/arrows/WS.png'/>.](images/app.statdx.com_image_thumbnail_8434672d-6281-4521-ab2c-d09f5e17b548_size_168_quality_85_86c243fe_20251014T185335Z.jpg)
![Axial Tc-99m ECD SPECT in a patient with multiinfarct dementia shows multiple infarcts of the frontal and parietal cortex <img src='img/arrows/WS.png'/>.](8434672d-6281-4521-ab2c-d09f5e17b548)
*Axial Tc-99m ECD SPECT in a patient with multiinfarct dementia shows multiple infarcts of the frontal and parietal cortex <img src='img/arrows/WS.png'/>.*
![Surface-rendered Tc-99m ECD SPECT in the same patient shows asymmetric cortical findings <img src='img/arrows/WS.png'/>.](images/app.statdx.com_image_thumbnail_cb09e173-1ef7-440a-8c92-0dfe31c76630_size_168_quality_85_e2d1c8bf_20251014T185335Z.jpg)
![Surface-rendered Tc-99m ECD SPECT in the same patient shows asymmetric cortical findings <img src='img/arrows/WS.png'/>.](cb09e173-1ef7-440a-8c92-0dfe31c76630)
*Surface-rendered Tc-99m ECD SPECT in the same patient shows asymmetric cortical findings <img src='img/arrows/WS.png'/>.*
![Surface-rendered Tc-99m ECD SPECT in a patient with history of cocaine abuse and early dementia shows diffuse cortical findings.](images/app.statdx.com_image_thumbnail_344c72d7-e6ba-4274-8a15-d9b9f7cace6d_size_168_quality_85_7371e27d_20251014T185335Z.jpg)
![Surface-rendered Tc-99m ECD SPECT in a patient with history of cocaine abuse and early dementia shows diffuse cortical findings.](344c72d7-e6ba-4274-8a15-d9b9f7cace6d)
*Surface-rendered Tc-99m ECD SPECT in a patient with history of cocaine abuse and early dementia shows diffuse cortical findings.*
![Surface-rendered Tc-99m ECD SPECT in a patient with history of methamphetamine abuse and early dementia is shown.](images/app.statdx.com_image_thumbnail_74ffbc46-1f77-45b4-a13a-22a16305c4ef_size_168_quality_85_cd398f87_20251014T185335Z.jpg)
![Surface-rendered Tc-99m ECD SPECT in a patient with history of methamphetamine abuse and early dementia is shown.](74ffbc46-1f77-45b4-a13a-22a16305c4ef)
*Surface-rendered Tc-99m ECD SPECT in a patient with history of methamphetamine abuse and early dementia is shown.*