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---
title: "Craniocervical Junction Acute Injury"
docid: "89ec23bf-2ed4-4694-98a7-7064d22cbf16"
authors:
- key: "bee1f359-33fb-4cba-9e6b-ed1ca1842439"
value: "Jeffrey S. Ross, MD"
- key: "86b8c311-8667-4afd-9b2b-0c2036a02b8a"
value: "Julia R. Crim, MD"
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name: "Spine"
slug: "spine"
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name: "Differential Diagnosis"
slug: "differential-diagnosis"
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name: "Craniovertebral Junction"
slug: "craniovertebral-junction"
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name: "Anatomically Based Differentials"
slug: "anatomically-based-differentials"
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name: "Craniocervical Junction Acute Injury"
slug: "craniocervical-junction-acute-inju-"
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category: "Spine"
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lastUpdated: "02/02/23"
pageDescription: "Craniocervical Junction Acute Injury"
pageKeywords: "Spine, Differential Diagnosis, Craniovertebral Junction, Anatomically Based Differentials, Craniocervical Junction Acute Injury"
pageTitle: "Craniocervical Junction Acute Injury | STATdx"
enhancedTitle: "Craniocervical Junction Acute Injury"
type: "DDX"
breadcrumbs:
- "Spine"
- "Differential Diagnosis"
- "Craniovertebral Junction"
- "Anatomically Based Differentials"
- "Craniocervical Junction Acute Injury"
---
# ESSENTIAL INFORMATION
- ## Key Differential Diagnosis Issues
- Coronal, sagittal CT reformations essential for full evaluation of injury
- MR very useful to evaluate for ligament injuries, cord injury, disc herniations
- CT angiogram equally accurate (and faster) than MR angiogram for vertebral dissection
- Time is often of essence in these patients, who tend to have multiple injuries
- ## Helpful Clues for Common Diagnoses
- **Occipital Condyle Fracture**
- CT best method of diagnosis
- Symptoms and outcome determined by associated head injury
- Cranial nerve deficits in 30%
- **Jefferson C1 Fracture**
- If combined displacement of lateral masses > 6.9 mm, unstable
- High likelihood of other fractures: Spine, skull, pelvis, lower extremity
- **Odontoid C2 Fracture**
- Usually low-velocity injury in older adult
- Type II most frequent
- **Chronic Injury Mimics**
- **Os odontoideum**
- Chronic, nonunited odontoid fracture
- Smooth corticated margins
- **Nontraumatic Mimics**
- **Pseudosubluxation C2-C3**
- Children < 10 years old; anterolisthesis may measure up to 4 mm
- ## Helpful Clues for Less Common Diagnoses
- **Atlantoccipital Dislocation**
- High incidence of cord injury
- Formerly usually fatal; now patients often survive to hospital
- **Atlantoaxial Dislocation**
- Normal atlantoaxial joint space < 3.4 mm in adults on CT
- **Spinal Cord Injury Without Radiographic Abnormality (SCIWORA)**
- Occurs primarily in children
- MR: Injuries to cord, ligaments, intervertebral discs, cartilaginous endplates
- 2/3 of severe cervical injuries in children < 8 years are SCIWORA
## Images
### Selected Images
![Coronal NECT shows a nondisplaced occipital condyle fracture <img src='img/arrows/WS.png'/> as well as a C4 articular pillar fracture <img src='img/arrows/WO.png'/>, reflecting lateral flexion injury.](images/app.statdx.com_image_thumbnail_22402513-d562-489c-8431-9e1d973aedc7_annotated_true_size_900_quality_90_19489e91.jpg)
**Occipital Condyle Fracture**
*Coronal NECT shows a nondisplaced occipital condyle fracture <img src='img/arrows/WS.png'/> as well as a C4 articular pillar fracture <img src='img/arrows/WO.png'/>, reflecting lateral flexion injury.*
![Coronal NECT shows a nondisplaced occipital condyle fracture <img src='img/arrows/WS.png'/> as well as a C4 articular pillar fracture <img src='img/arrows/WO.png'/>, reflecting lateral flexion injury.](images/app.statdx.com_image_thumbnail_22402513-d562-489c-8431-9e1d973aedc7_size_174_quality_85_bd3c6fac.jpg)
**Occipital Condyle Fracture**
*Coronal NECT shows a nondisplaced occipital condyle fracture <img src='img/arrows/WS.png'/> as well as a C4 articular pillar fracture <img src='img/arrows/WO.png'/>, reflecting lateral flexion injury.*
![Axial CT shows a type 3 condyle fracture <img src='img/arrows/WS.png'/> rotated into the foramen magnum. Note the normal position of the right condyle <img src='img/arrows/WO.png'/>.](images/app.statdx.com_image_thumbnail_31a951d8-aba5-459c-b13e-2f69d8276bff_annotated_true_size_900_quality_90_23074150.jpg)
**Occipital Condyle Fracture**
*Axial CT shows a type 3 condyle fracture <img src='img/arrows/WS.png'/> rotated into the foramen magnum. Note the normal position of the right condyle <img src='img/arrows/WO.png'/>.*
![Axial bone CT shows multiple fractures of the C1 ring <img src='img/arrows/WS.png'/>. Lateral displacement in this patient indicates rupture of the transverse ligament of dens and resultant instability.](images/app.statdx.com_image_thumbnail_19499959-3e5b-48bd-9b30-b909cff6d8b0_annotated_true_size_900_quality_90_7d2689c1.jpg)
**Jefferson C1 Fracture**
*Axial bone CT shows multiple fractures of the C1 ring <img src='img/arrows/WS.png'/>. Lateral displacement in this patient indicates rupture of the transverse ligament of dens and resultant instability.*
![Parasagittal CT shows a condyle fracture <img src='img/arrows/WS.png'/> that has maintained its relationship with the lateral mass of C1 <img src='img/arrows/WO.png'/> despite the posterior displacement.](images/app.statdx.com_image_thumbnail_2f771c4a-f8d7-4d16-a80f-6355efe3eb0b_annotated_true_size_900_quality_90_a2de4bd8.jpg)
**Occipital Condyle Fracture**
*Parasagittal CT shows a condyle fracture <img src='img/arrows/WS.png'/> that has maintained its relationship with the lateral mass of C1 <img src='img/arrows/WO.png'/> despite the posterior displacement.*
![Sagittal NECT shows a type 2 dens fracture <img src='img/arrows/WS.png'/> in an osteoporotic patient. Soft tissue swelling is mild. These fractures are commonly subtle on radiographs and best seen on lateral (not odontoid) view. If there is any question, perform CT.](images/app.statdx.com_image_thumbnail_3dadafa9-51c9-4e1a-ab36-c6d405d30c98_annotated_true_size_900_quality_90_b8da6fbe.jpg)
**Odontoid C2 Fracture**
*Sagittal NECT shows a type 2 dens fracture <img src='img/arrows/WS.png'/> in an osteoporotic patient. Soft tissue swelling is mild. These fractures are commonly subtle on radiographs and best seen on lateral (not odontoid) view. If there is any question, perform CT.*
![Plain radiograph shows a fracture through the base of the odontoid <img src='img/arrows/WS.png'/>, which is displaced posteriorly with slight extension.](images/app.statdx.com_image_thumbnail_aa3c67e2-3714-401d-9f44-21a90698c14a_annotated_true_size_900_quality_90_8f8bc33f.jpg)
**Odontoid C2 Fracture**
*Plain radiograph shows a fracture through the base of the odontoid <img src='img/arrows/WS.png'/>, which is displaced posteriorly with slight extension.*
![Sagittal bone CT shows a comminuted C2 body fracture with characteristic retropulsion of the posterior cortex <img src='img/arrows/WS.png'/>. Additional burst fractures are commonly present elsewhere in the spine.](images/app.statdx.com_image_thumbnail_16441d90-afd1-4d99-92d6-89b22dd6b410_annotated_true_size_900_quality_90_84149ae5.jpg)
**Burst Fracture, C2**
*Sagittal bone CT shows a comminuted C2 body fracture with characteristic retropulsion of the posterior cortex <img src='img/arrows/WS.png'/>. Additional burst fractures are commonly present elsewhere in the spine.*
![Sagittal T1WI MR shows a well-defined fracture line <img src='img/arrows/WO.png'/>. MR is useful for defining soft tissue abnormalities but should not be relied upon for pure bony fracture identification.](images/app.statdx.com_image_thumbnail_6bf9d862-33fc-4cb3-9dde-9479af9438bb_annotated_true_size_900_quality_90_c1ef2150.jpg)
**Odontoid C2 Fracture**
*Sagittal T1WI MR shows a well-defined fracture line <img src='img/arrows/WO.png'/>. MR is useful for defining soft tissue abnormalities but should not be relied upon for pure bony fracture identification.*
![Sagittal oblique 3D CT shows bilateral C2 pedicle fractures <img src='img/arrows/WS.png'/> without fracture of the vertebral body. Effendi classification uses the presence of disruption of the C2-C3 disc and facet joints as a measure of the severity of injury.](images/app.statdx.com_image_thumbnail_dcf76a6a-f291-4769-9c32-5adff2b85b11_annotated_true_size_900_quality_90_f006a904.jpg)
**Hangman's C2 Fracture**
*Sagittal oblique 3D CT shows bilateral C2 pedicle fractures <img src='img/arrows/WS.png'/> without fracture of the vertebral body. Effendi classification uses the presence of disruption of the C2-C3 disc and facet joints as a measure of the severity of injury.*
![3D CT reconstruction visualizes the markedly left rotated C1 <img src='img/arrows/WS.png'/> with respect to the mildly rotated C2 <img src='img/arrows/WO.png'/>. Findings are typical of a Fielding-Hawkins type I atlantoaxial rotatory fixation.](images/app.statdx.com_image_thumbnail_389cbe27-130d-43d4-bb61-0de9b7351a60_annotated_true_size_900_quality_90_4a71dae3.jpg)
**Atlantoaxial Rotary Subluxation/Fixation**
*3D CT reconstruction visualizes the markedly left rotated C1 <img src='img/arrows/WS.png'/> with respect to the mildly rotated C2 <img src='img/arrows/WO.png'/>. Findings are typical of a Fielding-Hawkins type I atlantoaxial rotatory fixation.*
![Sagittal bone CT shows a chronic, nonunited dens fracture <img src='img/arrows/WS.png'/>, so-called os odontoideum. This may be unstable, and flexion-extension views should be performed.](images/app.statdx.com_image_thumbnail_be54fabc-1abd-4497-9a41-d0026f038bee_annotated_true_size_900_quality_90_7bd5114c.jpg)
**Os Odontoideum**
*Sagittal bone CT shows a chronic, nonunited dens fracture <img src='img/arrows/WS.png'/>, so-called os odontoideum. This may be unstable, and flexion-extension views should be performed.*
![Axial bone CT shows anterior and posterior clefts <img src='img/arrows/WO.png'/> of C1. Smooth, corticated margins are signs distinguishing this from trauma.](images/app.statdx.com_image_thumbnail_8d090e1e-c409-4243-8174-776cc1e1a3b5_annotated_true_size_900_quality_90_badad089.jpg)
**Craniovertebral Junction Variants**
*Axial bone CT shows anterior and posterior clefts <img src='img/arrows/WO.png'/> of C1. Smooth, corticated margins are signs distinguishing this from trauma.*
![Sagittal bone CT shows the anterior arch of C1 fused to the clivus <img src='img/arrows/WS.png'/> and posterior arch fused to C2 <img src='img/arrows/WO.png'/>.](images/app.statdx.com_image_thumbnail_f24c53ea-0379-4092-ace0-2ae942371b20_annotated_true_size_900_quality_90_b395b841.jpg)
**Craniovertebral Junction Variants**
*Sagittal bone CT shows the anterior arch of C1 fused to the clivus <img src='img/arrows/WS.png'/> and posterior arch fused to C2 <img src='img/arrows/WO.png'/>.*
![Parasagittal CT shows posterior displacement of the lateral mass of C1 with respect to the occipital condyle <img src='img/arrows/WO.png'/>. The normal condyle would be closely applied to the lateral mass of C1.](images/app.statdx.com_image_thumbnail_407a344a-a2cd-40a5-8118-8c26359f3560_annotated_true_size_900_quality_90_4224ccac.jpg)
**Atlantooccipital Dislocation**
*Parasagittal CT shows posterior displacement of the lateral mass of C1 with respect to the occipital condyle <img src='img/arrows/WO.png'/>. The normal condyle would be closely applied to the lateral mass of C1.*
![Sagittal CT shows widening of the basion-dental interval <img src='img/arrows/WS.png'/> and slight posterior displacement of the odontoid with respect to the foramen magnum <img src='img/arrows/WC.png'/> (i.e., abnormal Wackenheim clival line).](images/app.statdx.com_image_thumbnail_a1a12cf6-aa3c-46c9-a6a9-4d2a23636c49_annotated_true_size_900_quality_90_26665e78.jpg)
**Atlantooccipital Dislocation**
*Sagittal CT shows widening of the basion-dental interval <img src='img/arrows/WS.png'/> and slight posterior displacement of the odontoid with respect to the foramen magnum <img src='img/arrows/WC.png'/> (i.e., abnormal Wackenheim clival line).*
![Parasagittal CT shows slight widening of both C0-C1 <img src='img/arrows/WS.png'/> and C1-C2 <img src='img/arrows/WO.png'/> articulations in this patient with both atlantooccipital and atlantoaxial subluxations.](images/app.statdx.com_image_thumbnail_98037363-0472-44eb-8b5a-fc14ec05b686_annotated_true_size_900_quality_90_c0a16653.jpg)
**Atlantooccipital Dislocation**
*Parasagittal CT shows slight widening of both C0-C1 <img src='img/arrows/WS.png'/> and C1-C2 <img src='img/arrows/WO.png'/> articulations in this patient with both atlantooccipital and atlantoaxial subluxations.*
![Sagittal STIR MR shows diffuse prevertebral high signal from edema <img src='img/arrows/WS.png'/> and a widened basion-dental interval <img src='img/arrows/WO.png'/>. Note the disruption of the tectorial membrane <img src='img/arrows/WC.png'/>.](images/app.statdx.com_image_thumbnail_8f33afe7-f373-4a01-8367-1326adb50a2f_annotated_true_size_900_quality_90_48528ce6.jpg)
**Atlantooccipital Dislocation**
*Sagittal STIR MR shows diffuse prevertebral high signal from edema <img src='img/arrows/WS.png'/> and a widened basion-dental interval <img src='img/arrows/WO.png'/>. Note the disruption of the tectorial membrane <img src='img/arrows/WC.png'/>.*
![Sagittal STIR MR shows abnormal hyperintensity within the C0-C1 and C1-C2 articulations <img src='img/arrows/WC.png'/> due to simultaneous atlantooccipital and atlantoaxial subluxations. The 2-level abnormality is important to identify since the posterior fusion will be extended more inferiorly.](images/app.statdx.com_image_thumbnail_97696e35-2c9f-4005-ad52-e16beb479377_annotated_true_size_900_quality_90_d3b240bb.jpg)
**Atlantoaxial Dislocation**
*Sagittal STIR MR shows abnormal hyperintensity within the C0-C1 and C1-C2 articulations <img src='img/arrows/WC.png'/> due to simultaneous atlantooccipital and atlantoaxial subluxations. The 2-level abnormality is important to identify since the posterior fusion will be extended more inferiorly.*
![Coronal CT shows the disrupted spinal articulations at C1-C2 (atlantoaxial dissociation). There is widening of the atlantoodontoid articulation <img src='img/arrows/WS.png'/> and widening/dislocation of the lateral masses of C1 and C2 <img src='img/arrows/WC.png'/>.](images/app.statdx.com_image_thumbnail_0c22bdc8-8b24-422e-b106-286a9b4aa82a_annotated_true_size_900_quality_90_7d289946.jpg)
**Atlantoaxial Dislocation**
*Coronal CT shows the disrupted spinal articulations at C1-C2 (atlantoaxial dissociation). There is widening of the atlantoodontoid articulation <img src='img/arrows/WS.png'/> and widening/dislocation of the lateral masses of C1 and C2 <img src='img/arrows/WC.png'/>.*
![Sagittal CT shows gross widening of the atlantoodontoid articulation <img src='img/arrows/WS.png'/>. The ring of C1 has maintained position with respect to the foramen magnum <img src='img/arrows/WO.png'/>, but C2 is displaced posteriorly <img src='img/arrows/WC.png'/>.](images/app.statdx.com_image_thumbnail_28794e41-818e-4487-ad3b-e985c6c7189e_annotated_true_size_900_quality_90_edba48d6.jpg)
**Atlantoaxial Dislocation**
*Sagittal CT shows gross widening of the atlantoodontoid articulation <img src='img/arrows/WS.png'/>. The ring of C1 has maintained position with respect to the foramen magnum <img src='img/arrows/WO.png'/>, but C2 is displaced posteriorly <img src='img/arrows/WC.png'/>.*
### Additional Images
![Sagittal bone CT shows occipital condyle <img src='img/arrows/BC.png'/> widely separated from lateral mass of C1 <img src='img/arrows/WC.png'/>, indicating longitudinal atlantooccipital dislocation. Dislocation may also be anterior or posterior in direction.](images/app.statdx.com_image_thumbnail_63bcd917-55ed-466c-b898-55064cf3cd8a_annotated_true_size_900_quality_90_234d1fdf.jpg)
**Atlantooccipital Dislocation**
*Sagittal bone CT shows occipital condyle <img src='img/arrows/BC.png'/> widely separated from lateral mass of C1 <img src='img/arrows/WC.png'/>, indicating longitudinal atlantooccipital dislocation. Dislocation may also be anterior or posterior in direction.*